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Medication Transfer to Breast Milk: What We Know and Don't Know Breast milk drug concentration depends on molecular properties, maternal metabolism, and lactation stage

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The triple receptor mechanism, hitting GLP-1, GIP, and glucagon simultaneously, appears to drive more total energy expenditure than dual or single receptor drugs

It acts as a non-selective melanocortin receptor agonist with the following binding profile (approximate Ki values): MC1R : ~0.67 nM (highest affinity, melanogenesis) MC4R : ~6.6 nM (appetite suppression, sexual function) MC3R : ~34 nM (energy balance) MC5R : ~46 nM (exocrine gland function) This broad receptor profile produces multiple physiological effects

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